MIR is a computational method to infer relative activities miRNAs by integrating microarray expression data with miRNA target predictions.


WinMIR.exe: Program executable in Microsoft Windows system. The program is coded in C++ and complied with Visual Studio 6.0.

UnixMIR: Program executable in UNIX system.

Readme: description about format of input and output files for the above program.

Example microarray data: miRNA transfection data with 14 expression change profiles. Relative expressions of genes are measured using two-channel arrays after miRNA transfection into Hela cells.

Example miRNA-gene binding affinity data: Binding affinity profiles of 211 human miRNA to genes.

Run.bat: An example to show how to run the program.

Example output file: An example output file


[1] Cheng C, Yan X, Sun F, Li LM. Inferring activity changes of transcription factors by binding association with sorted expression profiles. BMC Bioinformatics. 2007 Nov 16;8:452. [Pubmed]

[2] Cheng C, Li LM. Inferring microRNA activities by combining gene expression with microRNA target prediction. PLoS One. 2008 Apr 23;3(4):e1989. [Pubmed]


Chao Cheng

Lei Li